![]() ![]() We also demonstrated evidence of modest mediation between CHIP and CAD by mLTL. Bidirectional Mendelian randomization studies were consistent with longer genetically imputed LTL increasing propensity to develop CHIP, but CHIP then, in turn, hastens to shorten measured LTL (mLTL). Here, we investigated the relationship between CHIP, LTL, and CAD in the Trans-Omics for Precision Medicine (TOPMed) program ( n = 63,302) and UK Biobank ( n = 47,080). TERT (which encodes telomerase reverse transcriptase) is the most significantly associated germline locus for CHIP in genome-wide association studies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy and CAD. ![]() Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Mathias, Ron Do, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, and Pradeep Natarajan Show Fewer Samani, Siddhartha Jaiswal, Peter Libby, Patrick T. Silverman, Charles Kooperberg, John Danesh, Nilesh J. McGarvey, Mariza de Andrade, Yii-Der Ida Chen, Robert C. Heckbert, Jiang He, Wendy Post, Donna K. Minster, The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, Ranjan Deka, Take T. Peyser, Dandi Qiao, Pinkal Desai, Joanne E. Irvin, Meher Boorgula, Wei Zhao, Lisa R. Stilp, Quenna Wong, Jai Broome, Cecelia A. Clarke, Romit Bhattacharya, Themistocles L. Weinstock, Akhil Pampana, Christopher J. Carty, … Show All …, John Lane, Michael C. The following databases contain transcript sequences: Reference mRNA (refseqmrna), Nucleotide collection (nr/nt), and the EST databases.Click the BLAST button to run the search and identify matching sequences.Tetsushi Nakao, Alexander G. For a protein sequence, select the blastx translating service. ![]() Include the organism in the search to find the most relevant results and filter for transcript sequences, for example: Cytochrome c AND bullfrogorgn AND mrnafilter.A NUCLEOTIDE OR PROTEIN SEQUENCE.Use the NCBI BLAST service to perform a similarity search.For a nucleotide sequence select the nucleotide blast service from the Basic BLAST section of the. Transcript sequences are not produced for prokaryotes.If there is no gene record for the organism and gene of interest, perform a search in the database with the gene name, product name, or symbol.Click on the UniGene cluster of interest.The UniGene cluster has links to transcript sequences for the gene from the Nucleotide and EST databases.If there is no UniGene cluster for this gene and organism, perform a search in the database with the gene name, product name, or symbol. If you know the gene symbol and species, enter them as follows: tposym AND humanorgn.Click on the desired gene.Click on Reference Sequences in the Table of Contents at the upper right of the gene record.The NCBI Reference Sequences section of the record has links to NCBI curated records for transcripts (NM and XM prefix reference sequences) for the gene of interest for eukaryotic organisms. Starting with.A GENE NAME, PRODUCT NAME, OR SYMBOL.Search the database with the gene name, symbol. ![]()
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